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Glucagon receptor activation is the key mechanistic difference between retatrutide and tirzepatide
Some studies have shown that GLP-1RAs act on the hypothalamus to promote satiety and reduce food intake, inhibit gastric emptying [52], thereby leading to weight loss and potentially improving upper airway collapsibility
If cost is a barrier, a lower or less frequent dose may be a reasonable, pragmatic approach, recognizing that this needs to be individualized with close monitoring
Discuss with your GP or endocrinologist before starting Ozempic to ensure individualised assessment of suitability, monitoring requirements, and potential medication adjustments
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