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While their mechanisms may differ, their combination has been proposed to provide complementary or synergistic actions

FoB for Gclc fl/fl , or FoB Gclc fl/fl Mb1 Cre + vs

As a transcriptional coactivator, Nrf2 inhibits ferroptosis through target genes such as GPX4 and G6PD [85, 86]

It has been proposed that -tocopherol can also scavenge superoxide, as suggested by experiments with submitochondrial particles isolated from mice fed with vitamin-E supplemented diet ( Although the dismutation of superoxide by SOD2 is a predominant source of H 2 O 2 , there are other reactions that directly generate H 2 O 2 in mitochondria