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The Phase 3 results confirm that Retatrutide at 12mg produces the highest weight loss ever recorded in an obesity medication trial, with nearly 29% average reduction at 68 weeks

Specific strategies: Return to full training programs (3-4 sets per exercise) Attempt modest strength increases when possible Add 1-2 isolation exercises per session for body composition refinement Consider increasing training frequency (3 to 4 days weekly if recovery permits) Implement moderate cardio (2-3 sessions weekly, 20-30 minutes) Track body composition monthly via DEXA scan or bioimpedance if accessible Performance expectations: Most patients maintain strength during this phase

doi: 10.1111/dom.70209

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