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Oral administration of GSH is not very effective, however, because it is poorly absorbed through digestion and insufficient amounts cross the blood-brain barrier
Consistent with this, pulmonary glutathione levels also display marked circadian variation, suggesting tight circadian control of this antioxidant pathway (59)
In the study conducted by Nachvak et al., L-carnitine supplementation significantly increased serum total antioxidant capacity (TAC) and significantly reduced levels of myeloperoxidase (MPO), nitrotyrosine (NT), and high-sensitivity C-reactive protein (hs-CRP) compared to the placebo group
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