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Hyperglycemia induces metabolic and cellular stress that drives VEGF signaling, mitochondrial superoxide production, and induces persistent epigenetic changes, thereby priming inflammatory signaling in glia and endothelial cells ( In human retinal endothelial cells, high glucose is associated with lipidomic shifts consistent with increased PUFA oxidation that promote NADPH oxidase activation and tight-junction disruption
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Healthspan goes beyond medication
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