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Although I do not routinely measure longitudinal change in body composition or bone mass in people taking GLP-1s, mostly because of the cost of DXA scans, significant muscle or bone loss are two objective manifestations of excessive weight loss that should lead to stopping or slowing treatment
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Subjects exposed to at least one dose of semaglutide and with at least one valid PK measurement were included in the data set, which included dosing information for all recorded injections, semaglutide concentrations, and covariate values
As tirzepatide is a relatively new medication whose side effect profile has yet to be fully characterized, clinicians should be aware of this rare yet potentially fatal complication. Although GLP-1 receptor agonists show impressive efficacy and favorable side effect profiles, it is necessary that we determine all risks and side effects, particularly rare ones, to minimize chances of poor outcomes, says the papers first author Eli J
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