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Melanotan-1 (afamelanotide) selectively activates MC1R receptors for melanin production, while Melanotan-2 activates MC1R, MC3R, MC4R, and MC5R a broader receptor profile that produces faster tanning but also systemic side effects including increased libido, appetite suppression, nausea, and transient hypertension

Common side effects of semaglutide include nausea, vomiting, and diarrhea, with back pain being much less frequent

It is important to note that while the active ingredients are often the same as those found in branded products, compounded medications themselves are not FDA-approved

Safety and tolerability in older age groups, polypharmacy, kidney, and hepatic impairment