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Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline

The urothelium of the bladder mucosa has a strong barrier effect, which can prevent drug molecules from passing through, especially for the penetration of macromolecules or water-soluble drugs, affecting the depth of drug action on tumor cells ( In response to the above issues, researchers are developing new local drug-delivery systems to enhance drug adhesion and penetration into the bladder

The Arg3 substitution and N-terminal 13-residue extension in IGF-1 LR3 reduce IGFBP affinity by approximately 1,000-fold, preventing this sequestration

doi: 10.1080/15548627.2022.2062887 129 WuDHuQWangYJinMTaoZWanJ