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In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels

GSH is the most abundant and ubiquitous antioxidant in cells

"Risk of cutaneous melanoma associated with pigmentation characteristics and freckling: systematic overview of 10 case-control studies