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Short-term trials (412 weeks) report transient headaches in 1218% of participants and mild gastrointestinal discomfort (nausea, bloating) in approximately 8% of users
They designed and synthesized a series of biodegradable NOArg-Arg PEA copolymers with different ratios, which released L-Arg to prevent its depletion in the wound environment, while the released NOS inhibitors suppressed excessive production of NO, thereby maintaining appropriate NO levels (Fig
Gmez-SolerMCordobillaBMoratXFernndez-DueasVDomingoJCiruelaF
Its therefore considered safe for long-term use instead of oral appetite suppressants
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