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Augmentation strategies for treatment resistant major depression: a systematic review and network meta-analysis

The underlying mechanisms involve alterations in intestinal permeability, abnormal microbial metabolites, the actions of neuroactive compounds, and regulation via the immune mediated MGBA

My recommended Melanotan 2 protocol is 0.25 mg injected subcutaneously, 1-2 times per week, which minimizes MC4R-driven side effects while still driving melanogenesis through MC1R