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b) recovering, semapeptide, wherein semapeptide amino acid sequence is Glu-Gly-Thr-Phe- Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg- Gly-Arg-Gly
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Initial assessment showed that the FITC conjugate peptides recapitulated the pharmacological properties of their unmodified counterparts, with similar binding affinity but reduced cAMP signalling potency for lixisenatide-FITC compared to exendin-4-FITC (Figure 3E, 3F)
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