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HIF-1 activation not only promotes metabolic reprogramming in tumor cells (e.g., enhancing glycolysis) but also induces vascular endothelial growth factor (VEGF) expression, leading to new blood vessel formation that supplies additional oxygen and nutrients to tumor cells ( Figure 2 Studies have shown that a low-iron environment can induce epithelial-mesenchymal transition (EMT), enhancing tumor cells' migratory and invasive abilities and increasing their metastatic potential

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