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FOCAL MELANOCYTIC PIGMENTATION Freckles/Ephelis Freckles is the lay term for ephelis and lentigines, which are commonly occurring, asymptomatic, wellcircumscribed, tan or browncolored macules often seen on sunexposed regions of the skin (Figure 53)

Triple Agonists (GLP-1/GIP/Glucagon) Drug-Drug Interaction Table At a glance Prototype drug / retatrutide (LY3437943) Mechanism / simultaneous GLP-1R, GIPR, and glucagon receptor agonism Phase 2 weight loss (48 wk) / 24.2% mean body weight reduction vs 2.1% placebo Primary metabolic targets / obesity, MASLD/MASH, T2D, dyslipidemia Gastric emptying effect / marked slowing, peak drug interaction risk 1 to 4 h post-dose Oral drug most affected / warfarin, oral contraceptives, levothyroxine, cyclosporine Hypoglycemia risk / low monotherapy