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An estimand accounts for these intercurrent events [Citation27], ensuring alignment of the objectives with the design, conduct, and analysis of a trial

Most of the trials and meta-analyses have shown inconsistent results about GLP-1 RAs in improving MASH-related fibrosis and propose more clinical trials assessing their efficacy on fibrosis according to baseline fibrosis stage and diabetes for more conclusive evidence

But, as scientists and food formulators learn more about how these drugs affect both diet and consumption patterns, its becoming clear that such consumers should not be treated as a single, monolithic segment

Cedars-Sinai has also noted that claims of immune-boosting benefits are largely anecdotal, and many benefits are not well supported scientifically