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The extent of weight loss likely also reflects the potency of anti-inflammatory effect, and biomarkers indicative of reduced inflammation have been shown to precede wight loss in multiple trials of this drug class
CrossRef The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure Xiaojing Qin, Shuang Wang, Zhanyao Yan, Ninghui Zhao, Jia Yao Frontiers in Microbiology .2025;[Epub] CrossRef Gut-Liver Axis: The Role of Intestinal Microbiota and Their Metabolites in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease Chao Cui, Shuai Gao, Jingfei Shi, Kai Wang Gut and Liver .2025
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Recent studies have uncovered increased DPP-4 expression and secretion from hepatocytes in obese mice, with a DPP-4 expression and activity much higher in the liver than in adipose tissue, indicating its emerging role as a hepatokine in the interplay between hepatocytes and adipocytes [4]
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