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Throughout clinical trials, these drugs have demonstrated efficacy for weight loss, as well as additional benefits in certain cases, including lowering the risk of diabetes, improving glycemic outcomes, and cardiovascular risk [21, 22]
3.3 Development of unimolecular agents targeting both GIPR and GLP-1R The anti-obesity effects of GIPR antagonism antibody, both alone and in combination with GLP-1RAs, have been demonstrated in preclinical models of mice and monkeys (68, 73)
Hormonal Balance Some studies also indicate that women using GLP-1s experienced decreased testosterone levels and more regular menstrual cycles
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