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This multi-functional activity positions GLP-1Rs as a class of medications that target the fundamental metabolic dysregulation driving SLD and the progression to advanced liver injury, thus establishing their role as a leading therapeutic strategy for managing the risk of advanced liver disease and HCC

241 Additionally, GLP-1(936) can effectively inhibit glucagon secretion induced by -adrenergic stimulation, amino acids, and membrane depolarization, indicating its inhibitory effect under various stimulatory conditions

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Garber A, Henry RR, Ratner R, Hale P, Chang CT, Bode B, et al