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For most patients stalling today, well-managed tirzepatide delivers substantial, sustainable results with a side-effect profile that is easier to tolerate than the highest-dose triple agonist

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By enhancing the transport of acyl-CoA into mitochondria for oxidation, TC cells can utilize fatty acids as an alternative energy source more efficiently, highlighting the importance of lipid metabolism in supporting the growth and survival of TC cells

However, when used chronically or at higher doses, that slowed motility can evolve into functional paralysis of the stomach, the hallmark of gastroparesis