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Intranasal insulin as a treatment for Alzheimers disease: a review of basic research and clinical evidence

Researchers have proposed several non-exclusive frameworks, including blood-brain-barrier transport of an endogenous peptide, interaction with the stress axis, circadian and pineal signalling via the alpha-1-adrenergic receptor (PMID 3029331), and neuroprotective activity

Although the primary endpoint here is the treatment of liver damage, one of the trials secondary endpoints is alcohol consumption

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