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The activation of these junctions may also induce long-term structural changes, such as the formation of tight associations with pericytes (which may encompass gene expression modulation), determining the stability and maturation of the vasculature [45], or short-lasting effects, like transient changes in endothelial permeability to solutes and circulating cells [46,47,48]

All mice received 2 days of 10 mL/kg body weight sterile saline subcutaneous injections before beginning the treatment phase to allow for acclimation to the handling and stress associated with injections