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Clinical studies indicate that GLP-1RAs therapy, in both diabetic and non-diabetic patients, results in a reduction in BMD, which is more pronounced at skeletal sites subjected to higher mechanical loading, such as the femur and tibia, and appears to correlate with the degree of weight loss

Based on how it went with Zepbound and Wegovy, expect limited insurance coverage at first, especially for weight loss (diabetes coverage tends to be better)

Relative to native endogenous hormones, the compound demonstrates enhanced potency at the human GIPR and comparatively reduced potency at the GCGR and GLP-1R [2]

A.ScisciolaL.PesapaneA.TaktazF.FranzeseM.et al (2023)