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This fixed-dose combination results in significant IOP reduction and offers a favorable safety profile for patients with OHT or POAG (NCT02829996)
Administration Route# Dihexa has a notable advantage in practical administration: its demonstrated oral bioavailability (approximately 38%) means it can be taken by mouth with meaningful CNS exposure
Jeong BY, Lee HY, Park CG, Kang J, Yu SL, Choi DR, Han S-Y, Park MH, Cho S, Lee SY, Hwang W-M, Yun S-R, Ryu H-M, Oh E-J, Park S-H, Kim Y-L, Yoon SH (2018b) Oxidative stress caused by activation of NADPH oxidase 4 promotes contrast-induced acute kidney injury
In other words, the schedule is a sensible default that a clinician can adjust, not a fixed rule you should try to bend on your own
