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Retatrutide treatment is a next-generation therapy for weight management that targets GLP-1, GIP, and glucagon receptors to regulate appetite, improve blood sugar control, boost fat metabolism, and increase energy levels
To reconcile the findings that both GIPR antagonists and GIPRAs reduce body weight, it is possible that physiological GIPR activity plays a permissive role in adipose tissue synthesis, while pharmacologically enhanced GIPR activity may reduce body weight through a different mechanism in the brain
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