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These medications exert (in)direct hepatic actions by reducing steatosis, attenuating inflammation, and potentially reversing fibrosis, while simultaneously addressing systemic metabolic abnormalities including excessive obesity, insulin resistance, and cardiovascular risk
The use of semaglutide was associated with improved clinical symptoms, physical activity, exercise function, quality of life, and more significant weight loss than the placebo group
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However, escalation within semaglutide was associated with a substantially higher probability of achieving a clinically meaningful incremental benefit ( 2 percentage points), suggesting that dose optimization within the same agent may be preferable when tolerated
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