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The L-cells are open-type triangular epithelial cells directly in contact with the lumen and neuro-vascular tissue and are accordingly stimulated by various nutrient, neural and endocrine factors

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Germ-free mouse models show persistently lower baseline BDNF and GDNF levels, altered dendritic spine shape, and impaired synaptic plasticity, highlighting the need of microbial signals for neurotrophic homeostasis [159]

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Wong and Billiar, 1995

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