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The risk of asthma is higher in children exposed to acetaminophen during pregnancy, and that risk is exacerbated by maternal genetic variants related to acetaminophen detoxification.[ref] Genetic interactions with acetaminophen: With multiple routes of detoxification, most people can take acetaminophen without liver damage

10.1530/REP-20-0015 48 MannervikB.linP.GuthenbergC.JenssonH.TahirM

Moreover, an enriched subgroup analysis of the URICOI-ICTUS trial revealed that UA treatment was safe, well-tolerated, and provided substantial benefits of UA in terms of the primary outcome(modified Rankin Scale score at day 90)

Retrospective analysis of OA progress in type 2 diabetes patients showed the lower ratio of knee arthroplasty in patients with Metformin treatment A systematic review of metformin use in patients with diabetes was conducted to explore if metformin treatment could influence OA progression in clinic setting