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2.1.1 Cellular components in TME of HCC Typical cellular components in TME of HCC consist of hepatic stellate cells (HSCs), cancer-associated fibroblasts (CAFs), endothelial cells, NKs, regulatory T cells (Tregs), myeloid-derived suppressor cell (MDSCs) and TAMs (Figure 1) (Tahmasebi Birgani and Carloni, 2017)