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Such designs would be smaller but more informative, because they test whether a pathway-defined phenotype responds to a pathway-matched intervention

[99] A person with cobalamin C disease, a rare autosomal, recessive, inheritance disease which results in combined methylmalonic aciduria and homocystinuria), [100] can be treated with intravenous or intramuscular hydroxocobalamin

If the underlying disease process has resolved and cobalamin body stores have been replenished, serum cobalamin concentration should be supranormal [higher than normal] at the time of reevaluation