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In CRISPR-engineered iPSC-derived microglia and neurons, plus primary autopsy microglia and brain tissue, SORL1 deletion triggered endoplasmic reticulum stress, interferon signaling, lipid-droplet accumulation, and impaired phagocytosis
Thrombosis and Vascular Inflammation in Diabetes: Mechanisms and Potential Therapeutic Targets
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In fact, the study authors stated that the epithalamin-treated patient group exhibited significantly lower mortality, decelerated aging, and normalized levels of melatonin production and lipid metabolism, compared to the control group [8]
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