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Human efficacy remains unproven
The impact of efflux transporters in the brain on the development of drugs for CNS disorders
GPX5 is an unusual member of the mammalian GPX family because, unlike the well-known mammalian GPX1-4, it does not contain selenosylcysteine (Secys) at its active site, but instead has cysteine residues (Cys) as its active site (Taylor et al., 2013)
(2022) showed a 78% reduction in ulcer surface area compared to control, accompanied by a marked increase in protective mucus production and epithelial cell proliferation
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