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Caution is advised in patients with Leber optic atrophy, a genetic disorder caused by chronic cyanide intoxication (such as from smoking, alcohol or some plants), against the use of cyano-B12 due to its cyanide moiety, whilst hydroxo-B12 is a cyanide antagonist and can therefore be used in these patients
In those cases the unit math changes a 0.25 mg dose at 3 mg/ml is about 8 units, not 25
I bought extra when Brexit was becoming a reality half knowing I could still be using it once the use by date had finished
Based on this analysis, specific recommendations and suggestions were developed for each disorder
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