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Structurally, melatonin is known to partition into membranes at the interface between the headgroup and tail group regions of the bilayer, generally resulting in an increase in the area per lipid, a decrease in the bilayer thickness, and a subsequent increase in membrane permeability [275]
However, as a result, Rocha indicates she suffered gastroparesis, which resulted in severe abdominal pain, nausea, vomiting, dehydration and permanent gastrointestinal injuries
Overuse can lead to side effects such as nausea, facial flushing, or fatigue
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