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Consistent with the data in intact atrial preparations, left atrial APD was prolonged throughout repolarization in db/db saline mice and normalized in db/db GLP-1 mice (Figure 6F to 6I)
This can indicate significant dehydration, electrolyte imbalance, or hypotension
Most patients experience gradual symptom improvement over weeks to months after discontinuation
Understanding semaglutide withdrawal symptoms versus degradation-related efficacy loss helps you distinguish between these very different scenarios and take the appropriate corrective action
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