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The Bridge program rules dictate that if a patient has a BMI of 35, but their sleep apnea crosses the threshold from mild to moderate, they are disqualified from gaining access to a GLP-1 through the Bridge initiative
More important, the concentration of GLP-1(2836) required for cardioprotection (6 nM) could not possibly be generated by degradation of the 20-fold lower amounts of the parent GLP-1 used in our experiments (0.3 nM)
As with any medication, they can have side effects
Nat Cell Biol 16:561573 Paranavitane V, Coadwell WJ, Eguinoa A, Hawkins PT, Stephens L (2003) LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin
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