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Most antibiotics, methotrexate, and pyrimethamine invalidate folic acid and vitamin B12 diagnostic microbiological blood assays
However, there have been cases of people breaking out into acne and rosacea and having heart palpitations after taking very high doses of vitamin B12, usually by injection
This higher dose can be administered as a single 100mg injection in the morning or split into two 50mg doses taken 12 hours apart (morning and afternoon)
after 1 month) can ensure a response
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