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When to contact your healthcare provider : You should seek medical advice if you experience: Severe or persistent nausea and vomiting preventing adequate fluid intake Signs of pancreatitis (severe abdominal pain radiating to the back) Gallbladder symptoms (pain in the right upper abdomen, fever, jaundice) Symptoms of hypoglycaemia if taking other diabetes medications Visual changes or worsening eyesight Severe allergic reactions (rash, swelling, breathing difficulties) Unexplained fatigue that worsens rather than improves These medications are not recommended during pregnancy or breastfeeding

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While there is a growing body of preclinical research suggesting metabolic benefits, robust human clinical trials particularly large-scale, randomised controlled trials (RCTs) are largely absent