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The removal of tiered systems in the NICE NG246 guideline on overweight and obesity management (NICE, 2025) signals a shift towards reconsidering access routes and care models for obesity management beyond the previous stepwise tiered system

both must be discarded after a single use Vials must never be shared between individuals Aseptic technique must be maintained throughout preparation and administration Disposal of sharps must comply with UK regulations

If adverse effects persist despite lifestyle changes, your doctor may need to prescribe other medications or adjust your dose

What likely matters most is consistency and following the products label instructions, since probiotic strains and formulations vary