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Glucagon receptor-mediated effects introduce additional considerations: Potential for transient increases in heart rate (also observed with GLP-1R agonists) Theoretical risk of hyperglycaemia from glucagon signalling, though phase 2 trial data suggest this is counterbalanced by concurrent GLP-1R and GIPR agonism In phase 2 trials, the most commonly reported adverse events were gastrointestinal in nature, consistent with the class
doi: 10.1016/S0140-6736(25)01185-7
A resting heart rate that has increased by more than 10 BPM warrants a conversation with your doctor
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