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13 In the SURPASS-4 trial (phase III), participants taking tirzepatide showed a much lower occurrence of composite kidney endpoint (time to first occurrence of eGFR decline of at least 40% from baseline, end-stage kidney disease, death due to kidney failure, or new onset albuminuria) compared with those who received insulin glargine (HR 0.58)

Ipamorelin mimics ghrelin and stimulates GH release with no significant increase in ACTH or cortisol (Raun et al., European Journal of Endocrinology )

Short Chain Fatty Acids (SCFAs) Unstructured reduced dietary intake is often associated with lower intake of fermentable fibers (found in onion, leeks, asparagus, legumes, oats, cooled oats and rice, apples, pears, carrots, etc.)