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Vigorous shaking can cause semaglutide molecules to aggregate at the air-liquid interface, creating foam and accelerating degradation

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for several indications: type 2 diabetes mellitus, chronic weight management, and more recently, to reduce the risk of major adverse cardiovascular events in adults with established cardiovascular disease and either overweight or obesity

Prescription injections bathe GLP-1 receptors in semaglutide all day, driving about 15 percent body-weight loss

Munkley J, Li L, Krishnan SRG, Hysenaj G, Scott E, Dalgliesh C, et al