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Since GLP-1 receptors exist throughout the gastrointestinal system and central nervous system, activation of these receptors produces the therapeutic benefits of appetite suppression and glucose regulation but also accounts for the predominant gastrointestinal side effects experienced by many users

In addition to the estimates of treatment on fracture risk, we have presented all covariate estimates from the main analysis of MOF in Supplemental Table S5

One study found that after stopping tirzepatide, nearly 7 out of 10 users regained more than 5% of the weight theyd lost within a year, moving closer to their original weight