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During 1,414,144 person-years of follow-up, cholangiocarcinoma occurred among 222 patients with use of DPP4 inhibitors (incidence rate, 26 per 100,000 patient-years) and among 128 patients with use of sulfonylureas (incidence rate, 23 per 100,000 patient-years)
Glucagon receptor activation: Increased hepatic glucose output under some conditions, increased energy expenditure, effects on hepatic lipid metabolism
mental and emotional factors play a significant role too
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