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During colonic mucosal repair, Lgr5-positive intestinal stem cells, driven by Wnt signaling, play a crucial role [8]

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Relevant UK guidance includes: NICE Technology Appraisal for semaglutide (Wegovy) in weight management sets out the criteria for use and monitoring in adults with obesity [4] [5] NICE guideline NG28: Type 2 diabetes in adults: management covers the use of incretin-based therapies in type 2 diabetes [6] NICE Technology Appraisal for tirzepatide (Mounjaro) in type 2 diabetes confirms the scope of UK recommendations for tirzepatide [7] [8] Your prescriber can help assess whether your symptoms are expected, manageable, or warrant a change in treatment

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