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IGF-1 is the primary mediator of GHs downstream effects in tissue, muscle, bone, and skin
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Sigalos and Pastuszak 2018, a review of the growth hormone secretagogue class covering GHRH analogs and GH-releasing peptides, concluded that these compounds are generally well tolerated but flagged decreased insulin sensitivity and elevated blood glucose as a consistent signal across the class, alongside a call for more long-term data on cancer incidence with sustained use
Giugliano D, Scappaticcio L, Longo M, Bellastella G, Esposito K
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