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In ISO-induced myocardial infarction, pretreatment with Gln maintained cardiac GSH kurtosis and antioxidant enzyme (GPX, SOD, CAT) activity at near-normal levels, thus preventing oxidative damage in the myocardium [111]

Clinical manifestations range from asymptomatic elevations in serum transaminases to more severe conditions, including cholestatic jaundice, peliosis hepatis, hepatic adenomas, and, in rare cases, hepatocellular carcinoma (75)

Based on the data available in 2015, EFSA did not identify any known health risks associated with the use of dietary supplements, so no maximum dose or maximum daily intake, also known as a tolerable upper intake, was set (EFSA, 2015)

He also doesn't distinguish between reduced glutathione (GSH) and oxidized glutathione (GSSG) for anyone who might be using a different formulation