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In this narrative review, we thoroughly trace the current preclinical and clinical evidence of seven pain modalities, including inflammatory pain, osteoarthritis, visceral pain, neuropathic pain, diabetic neuropathy, cancer pain and headache, to support the efficacy and underlying biological mechanisms of GLP-1RAs as therapeutic agents for pain suffering

Notably, both drugs had acceptable safety profiles

NADPH, a major cellular reductant, supports the enzymatic activity of FSP1, which resides on the plasma and outer mitochondrial membranes

Retatrutide is not an approved medicine and is not legally available for prescription use for any indication