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doi: 10.1177/0333102414544976 160
indole-3-propionic acid has been reported to protect against HFpEF, supporting microbiome-host metabolic axes as candidate modifiers of hypertrophic remodeling (62)
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In animal models, 1-methyl-4-phenol-1,2,5,6-tetrahydropyridine (MPTP) is used to induce destruction of dopaminergic neurons in the substantia nigra, mimicking human Parkinsons-like syndrome (111), while the infusion of BHB was found to have a protective role in dopaminergic neurodegeneration and motor deficits induced by MPTP (112)
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