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Research suggests several beneficial mechanisms: Improved insulin sensitivity : Insulin resistance is a key driver of PCOS symptoms, and GLP-1 medications can enhance insulin action Weight loss effects : Even modest weight reduction (510% of body weight) can restore ovulation and regular cycles in women with PCOS [17] [18] Reduced androgen levels : Weight loss and improved insulin sensitivity often lead to decreased testosterone and other androgens Restoration of ovulation : Some women with PCOS who previously had absent periods may begin ovulating regularly NICE Clinical Knowledge Summary on PCOS recommends lifestyle modification and weight loss as first-line interventions for overweight women with the condition

Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes

If you are not losing weight, or if you are losing weight too fast and feeling weak, look at your macros

The GIP component enhances fat metabolism and reduces hepatic glucose output, mechanisms that single-agonist GLP-1 drugs dont address