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All methods were carried out in accordance with relevant guidelines and regulations

a high-cardiovascular-risk kidney cohort showed a slower decline in kidney function and about a third less protein leak, which travels to a similar-risk body, not a healthy one. Lean and metabolically healthy: a safety read, not an efficacy target No long trial has tested tirzepatide in lean, metabolically healthy people

Patient education should emphasize the limited evidence base, experimental nature of treatment, and importance of ongoing monitoring

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